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July 22, 2025Open Access

Methylome-Wide Association Study of Obsessive-Compulsive Disorder

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Authors

KHKira HöfflerASAnne-Kristin StavrumMHMatthew Halvorsen

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Overview

Methylome-wide association study reveals 35 DMPs in OCD, implying genetic and immune system influences on the disorder.

Key Points

  • The methylome-wide association study identified 35 differentially methylated positions associated with obsessive-compulsive disorder.
  • Analysis included saliva DNA from 414 OCD individuals and 384 controls, utilizing the Illumina EPICv2 array.
  • Findings highlighted genetic variation related to methylation quantitative trait loci and immune system processes.
  • Sex-stratified analyses indicated distinct biological differences in DNA methylation between males and females.

Cite This Study

Höffler et al. (2025) studied this question.

synapsesocial.com/papers/689a0614e6551bb0af8cd6e3https://doi.org/10.1101/2025.07.18.25331794
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetics and Epigenetics of Obsessive–Compulsive Disorder2026 · 3 citations
  2. 2New Insights into the Oral Microbiota and Host Epigenetic changes in Obsessive Compulsive Disorder and Major Depressive Disorder: focus on BDNF2025 · 6 citations
  3. 3Genome-wide association study identifies new loci associated with OCD2024 · 8 citations
  4. 4Genome-wide association study identifies 30 obsessive-compulsive disorder associated loci2024 · 25 citations
  5. 5Exploring the Influence of DNA Methylation and family factors on OCD and symptoms Severity: Insights into the TPH2 Gene2024