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September 10, 2025Pharmacological ResearchOpen Access

New Insights into the Oral Microbiota and Host Epigenetic changes in Obsessive Compulsive Disorder and Major Depressive Disorder: focus on BDNF

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Authors

AGAntonio GirellaMVMatteo VismaraKOKenneth J. O’Riordan

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Overview

This research uncovers links between oral microbiota changes and BDNF in OCD and MDD, suggesting biomarkers for diagnosis.

Key Points

  • Significant alterations in oral microbiota composition were identified in patients with OCD and MDD.
  • OCD patients revealed increased levels of Actinobacteriota and Firmicutes, while MDD patients showed changes in Bacteroidota and Proteobacteria.
  • Post-streptococcal autoimmunity may contribute to the microbiota's role in OCD and MDD pathophysiology.
  • BDNF DNA methylation patterns were altered in both disorders, indicating unique epigenetic profiles.

Cite This Study

Girella et al. (2025) studied this question.

synapsesocial.com/papers/68c19f9c54b1d3bfb60db506https://doi.org/10.1016/j.phrs.2025.107891
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Altered oral microbiome composition in mental disorders: a systematic review and meta-analysis2025 · 9 citations
  2. 2Methylome-Wide Association Study of Obsessive-Compulsive Disorder2025 · 1 citations
  3. 3Potential value of oral Mogibacterium in major depressive disorder2026
  4. 4Oral Microbiota Taxa and Pri-miRNA Expression in Bipolar Disorder: A Case–Control Study2025
  5. 5Oral microbiota dysbiosis alters chronic restraint stress-induced depression-like behaviors by modulating host metabolism2024 · 30 citations