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August 4, 2025Journal of Oral MicrobiologyOpen Access

Altered oral microbiome composition in mental disorders: a systematic review and meta-analysis

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Authors

DCDunahua CaoJYJun YangYHYiwen He

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Overview

Systematic review examines microbial diversity in mental disorders, indicating potential biomarkers and treatment strategies.

Key Points

  • Altered oral microbiome composition was observed across patients with various mental disorders, suggesting a link between oral health and mental health.
  • The study revealed a significant increase in the Simpson Index for patients, demonstrating higher microbial diversity compared to controls (SMD = 0.42).
  • Notably, beta diversity differences were significant only in schizophrenia and major depressive disorder, indicating condition-specific microbial patterns.
  • These findings point to the oral microbiome as a possible candidate for future diagnostic tools and targeted therapies in mental health.

Cite This Study

Cao et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d0847https://doi.org/10.1080/20002297.2025.2541828
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