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July 21, 2025Journal of Clinical MedicineOpen Access

Association Between Oral Dysbiosis and Depression: A Systematic Review

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Authors

PGPaula García-RiosHospital General Universitario Morales MeseguerRPRaffaella PecciIstituto Superiore di SanitàMPMaría Pilar Pecci‐LloretHospital General Universitario Morales Meseguer

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Overview

Systematic review reveals strong association between oral microbiota alterations and depression, highlighting potential diagnostic biomarkers.

Key Points

  • Alterations in the oral microbiota composition and diversity are linked to depression.
  • A reduction in alpha diversity may indicate a local microbial imbalance in depressed patients.
  • Eleven studies were analyzed, showing significant potential for oral microbiota as a therapeutic target.
  • Methodological variability among studies calls for further research to solidify the association.

Cite This Study

García-Rios et al. (2025) studied this question.

synapsesocial.com/papers/689a0614e6551bb0af8cd4eehttps://doi.org/10.3390/jcm14145162
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The association of depression and oral microbiota2025 · 2 citations
  2. 2Variations in the oral microbiome are associated with depression in young adults2021 · 107 citations
  3. 3Altered oral microbiome composition in mental disorders: a systematic review and meta-analysis2025 · 9 citations
  4. 4Inflammatory biomarkers and oral microbiome alterations in depression and anxiety disorders: a systematic review2026
  5. 5Oral microbiota dysbiosis alters chronic restraint stress-induced depression-like behaviors by modulating host metabolism2024 · 30 citations