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July 22, 2025Open Access

Phenotypic Age and Neutrophil-to-Lymphocyte Ratio mediate the association between the triglyceride glucose-body mass index and the cardiovascular mortality risk in hypertensive patients.

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Authors

YPYu PanXLX.J. LIUSPShiyang Pan

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Overview

Analytical study links triglyceride glucose-body mass index with cardiovascular mortality in hypertensive patients, suggesting mediation by NLR and phenotypic age.

Key Points

  • Higher triglyceride glucose-body mass index levels correlate with increased cardiovascular mortality risk (HR 1.62, P=0.025).
  • This study followed 5164 hypertensive adults over an average of 8.33 years, identifying 1005 deaths, including from cardiovascular causes.
  • Structural equation modeling highlighted neutrophil-to-lymphocyte ratio and phenotypic age as mediators in the relationship between TyG-BMI and mortality.
  • Incorporating TyG-BMI, NLR, and phenotypic age into practice may enhance risk assessment in clinical settings.

Cite This Study

Pan et al. (2025) studied this question.

synapsesocial.com/papers/689a0614e6551bb0af8cd6e7https://doi.org/10.1101/2025.07.20.25331891
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The association of triglyceride-glucose index and related indices with all-cause and cardiovascular mortality in biologically aging populations2025 · 1 citations
  2. 2Association between triglyceride-glucose-body mass index and adverse prognosis in elderly patients with severe heart failure and type 2 diabetes: a retrospective study based on the MIMIC-IV database2025 · 7 citations
  3. 3Relationships of triglyceride–glucose index and body mass index with 5-year all-cause mortality in patients with diabetes and comorbid hypertension: Evidence from two prospective cohort studies2025 · 1 citations
  4. 4Association of triglyceride-glucose-body mass index with all-cause mortality among individuals with cardiovascular disease: results from NHANES2025 · 7 citations
  5. 5The association between novel metabolic parameters and all-cause/cardiovascular mortality in patients with metabolic syndrome is modified by age2025 · 19 citations