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July 22, 2025Frontiers in Cell and Developmental BiologyOpen Access

Characteristics and advances in signaling pathways, cellular communication, cell junctions, and oxidative stress in lymphedema

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Authors

QZQiancheng ZhaoZNZhipu NiuYPYing Pan

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Overview

Review summarizes signaling pathways and oxidative stress in lymphedema, suggesting multitarget therapies may improve treatment outcomes.

Key Points

  • Lymphedema is a chronic inflammatory disease with limited treatment options, leading to significant patient distress.
  • Key signaling pathways such as RAS/MAPK and PI3K/AKT are crucial for understanding lymphedema's progression.
  • Mutations in genes related to cell junctions disrupt lymphatic endothelial cell function, worsening the disease.
  • Understanding cellular communication among immune cells and lymphatic cells may help develop effective therapies for lymphedema.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/689a0614e6551bb0af8cd780https://doi.org/10.3389/fcell.2025.1521320
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  3. 3Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex2015 · 299 citations
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  5. 5Rapid identification of mutations in GJC2 in primary lymphoedema using whole exome sequencing combined with linkage analysis with delineation of the phenotype2011 · 119 citations