July 22, 2025

Lytic bacteriophages as alternative to overcoming antibiotic-resistant biofilms formed by clinically significant bacteria.

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Lytic bacteriophages offer a promising alternative to mitigate antibiotic-resistant biofilms in bacterial infections.
Biofilms complicate treatment, requiring up to 1000-fold higher antibiotic concentrations for eradication.
Phage enzymes disrupt biofilm components, enabling effective phage infection of bacterial cells.
Strategies such as phage-antimicrobial conjugation may enhance phage efficacy against biofilm resistance.

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Review highlights efficacy of phages against antibiotic-resistant biofilms formed by bacteria, suggesting new clinical strategies.

Osman et al. (2025) studied this question.

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