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July 22, 2025

Supplementary Data from IL18 Receptor Signaling Regulates Tumor-Reactive CD8⁺ T-cell Exhaustion via Activation of the IL2/STAT5/mTOR Pathway in a Pancreatic Cancer Model

Veronika Lutz Veronique M. Hellmund Felix S.R. Picard Hartmann Raifer Teresa Ruckenbrod Matthias Klein Tobias Bopp Rajkumar Savai Peter Duewell Corinna U. Keber Andreas Weigert Ho‐Ryun Chung Malte Buchholz André Menke Thomas M. Gress Magdalena Huber Christian Bauer

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Key Points

MAIN FINDING: IL18 receptor signaling plays a crucial role in regulating exhaustion of tumor-reactive CD8 T-cells in pancreatic cancer.
KEY EVIDENCE: Activation of the IL2/STAT5/mTOR pathway was identified as a significant mechanism in T-cell exhaustion.
APPROACH: The research involved a pancreatic cancer model to investigate T-cell responses and signaling pathways.
SIGNIFICANCE: Understanding this signaling could inform new therapeutic approaches for enhancing T-cell activity in pancreatic cancer.

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Implication

Study demonstrates IL18 receptor signaling regulates CD8 T-cell exhaustion in pancreatic cancer, highlighting IL2/stat5/mTOR pathway involvement.

Abstract

Supplementary Table S1-3 and Figures S1-6

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Cite This Study

Lutz et al. (2025) studied this question.

synapsesocial.com/papers/689a061be6551bb0af8cd932 https://doi.org/10.1158/2326-6066.29619003

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