Experimental findings show PCF11 and Cbc alter subnuclear localization in germ line cells, suggesting roles in RNA processing.
Stage specific increased expression of PCF11 and Cbc, the two components of Cleavage Factor complex II, contribute to developmentally regulated 3 UTR shortening due to alternate polyadenylation of nascent RNA molecules in Drosophila spermatocytes compared to spermatogonia. Here, we show that both Cbc and PCF11 change subnuclear localization during male germ cell differentiation, from homogeneous in the nucleus in spermatogonia and early spermatocytes to concentrated around the nucleolus in later spermatocyte stages.
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Nava et al. (2025) studied this question.
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