July 23, 2025NutrientsOpen Access

Targeting Oxidative Stress in Acute Pancreatitis: A Critical Review of Antioxidant Strategies

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Discussion

Critical review reveals mixed outcomes of antioxidant therapies in acute pancreatitis, suggesting potential and safety concerns.

Oxidative stress is a key factor in the development and severity of acute pancreatitis.
Clinical studies show conflicting results regarding the effectiveness of antioxidant therapy in humans.
Animal studies support the benefit of antioxidants, reducing oxidative injury and inflammation in pancreatitis.
Optimizing dosage and administration methods may improve the efficacy of antioxidants in treating acute pancreatitis.

Coman et al. (2025) studied this question.

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