Umbrella review synthesizes evidence on cardiovascular risk in psoriasis and psoriatic arthritis, indicating a need for clearer insights.
Psoriasis and psoriatic arthritis are chronic inflammatory diseases associated with increased cardiovascular (CV) risk. Several systematic reviews have investigated these associations, but findings remain heterogeneous and fragmented. This umbrella review aims to identify, appraise, and synthesize evidence from published systematic reviews and meta-analyses evaluating the link between PsO/PsA and cardiovascular risk factors, events, and subclinical atherosclerosis. A comprehensive literature search will be conducted across major databases. Data will be synthesized narratively, and the methodological quality of included reviews will be assessed using AMSTAR 2. This work will provide a consolidated understanding of the cardiovascular burden in PsO and PsA and inform both clinical and research priorities.
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Poncina et al. (2025) studied this question.
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