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July 23, 2025Open Access

Organ-specific immune responses are strain-dependent in a mouse model of Cryptococcus neoformans brain infection

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Authors

MFMan Shun FuInstitute of ImmunologyLGL. GeorgeInstitute of ImmunologyDHDaisy Harris-BosancicInstitute of Immunology

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Overview

This research demonstrates organ-specific immune responses influenced by cryptococcus neoformans strain in mice, suggesting key implications for understanding immunity.

Key Points

  • The study identifies varying immune responses in mouse models of cryptococcal meningitis based on the fungal strain used.
  • Quantification of myeloid and lymphoid cell recruitment reveals the role of cellular immunity during infection.
  • Organ-specific immunity patterns were observed, which did not directly correlate with fungal virulence potential.
  • Findings highlight the importance of strain selection in experimental models for better understanding immune responses.

Cite This Study

Fu et al. (2025) studied this question.

synapsesocial.com/papers/689a061be6551bb0af8cdb31https://doi.org/10.1101/2025.07.18.665331
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Organ-specific immune responses are strain-dependent in a mouse model of Cryptococcus neoformans brain infection2026 · 1 citations
  2. 2Cryptococcus neoforman s rapidly invades the murine brain by sequential breaching of airway and endothelial tissues barriers, followed by engulfment by microglia2024 · 33 citations
  3. 3Vaccine-Mediated Protection of Mice Against African and Asian Clinical Strains of Cryptococcus neoformans2025
  4. 4Unique recognition, phagocytosis, and intracellular survival of Cryptococcus neoformans in a human immortalized microglia cell line2025
  5. 5Neutrophils modulate the immune response to Cryptococcus neoformans 34562025