July 23, 2025

The effects of sleep disruption, sex, and mating status on susceptibility to fungal (Metarhizium anisopliae) infections in Drosophila melanogaster

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Discussion

Genetic analysis reveals that sleep disruption and sex affect disease resistance in Drosophila, suggesting key interactions with circadian rhythms.

Drosophila exhibit increased sleep after infection, showing a similar response to mammals.
Sleep-deprived Shaker mutants fail to exhibit sickness sleep and succumb quickly to fungal infections.
Mutations in per protect flies from disease, whereas mutations in Clk reduce survival, indicating pleiotropic effects.
Males and virgins show increased sleep and longer survival, emphasizing the role of sex and mating status in infection outcomes.

Nan et al. (2025) studied this question.

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Genetic analysis reveals that sleep disruption and sex affect disease resistance in Drosophila, suggesting key interactions with circadian rhythms.