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July 24, 2025Expert Review of Hematology

Mesenchymal stromal cells for the prophylaxis of graft-versus-host disease after hematopoietic stem cell transplantation: a meta-analysis of randomized controlled trials

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Authors

SRSushmitha RameshbabuHKHariniska Jayaraman KannanMMMudit Moondra

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Overview

Meta-analysis reveals that mesenchymal stromal cells improve overall survival and reduce graft-versus-host disease in hematopoietic stem cell transplant patients, suggesting a potential effective strategy.

Key Points

  • MSC prophylaxis significantly improves overall survival with a relative risk of 1.12 in HSCT patients.
  • There is a notable reduction in the incidence of acute GVHD and chronic GVHD with relative risks of 0.67 and 0.65, respectively.
  • The analysis included eight randomized controlled trials with a total of 570 patients, ensuring robust data for the findings.
  • No significant increase in relapse rates, infections, or adverse events was observed, indicating safety in MSC use for GVHD management.

Cite This Study

Rameshbabu et al. (2025) studied this question.

synapsesocial.com/papers/689a0621e6551bb0af8cded5https://doi.org/10.1080/17474086.2025.2535422
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mesenchymal stromal cells in the prophylaxis of graft vs host disease: A meta analysis2025
  2. 2The efficacy and safety of MSCs in GVHD prevention and the treatment of SR-aGVHD: a systematic review and meta-analysis of randomized controlled trials2026
  3. 3Mesenchymal stromal cells in the treatment of pediatric hematopoietic cell transplantation-related complications (graft vs. host disease, hemorrhagic cystitis, graft failure and poor graft function): a single center experience2024 · 6 citations
  4. 4Stromal Stem Cell Therapy for Prophylaxis of Acute GVHD: Preliminary Results From a Phase 1 Trial2011 · 2 citations
  5. 5Mesenchymal Stem/Stromal Cells: A Review for Its Use After Allogeneic Hematopoietic Stem Cell Transplantation2026 · 1 citations