Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 25, 2025Open Access

Archaic ancestry inference in imputed ancient human genomes

View Full Paper
Ask AI
Bookmark
Share

Authors

MCMarco Rosario CapodiferroTrinity College DublinLPLéo PlancheUniversité Paris-SaclayEBEmily M. BreslinThe University of Melbourne

Discussion

Loading...

Member takes

Implication

Imputation improves detection of archaic ancestry in ancient genomes, demonstrating accuracy in identifying Neanderthal and Denisovan segments.

Key Points

  • Main finding indicates that imputation enhances archaic ancestry inference in ancient genomes.
  • D-statistics and the f4-ratio show accuracy in detecting archaic introgression, confirming imputation reliability.
  • Imputation enables identification of Denisovan segments in Siberian and Alaskan individuals, enhancing genomic analysis.
  • Despite small sample size, origins of adaptive introgression genes in contemporary populations are effectively reconstructed.

Cite This Study

Capodiferro et al. (2025) studied this question.

synapsesocial.com/papers/689a0627e6551bb0af8cdf9chttps://doi.org/10.1101/2025.07.23.664192
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fast and accurate short read alignment with Burrows–Wheeler transform2009 · 64,150 citations
  2. 2Neanderthal ancestry through time: Insights from genomes of ancient and present-day humans2024 · 47 citations
  3. 3Detecting archaic introgression using an unadmixed outgroup2018 · 145 citations
  4. 4A high-coverage Neandertal genome from Chagyrskaya Cave2020 · 340 citations
  5. 5Population genomics of Mesolithic Scandinavia: Investigating early postglacial migration routes and high-latitude adaptation2018 · 268 citations