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July 25, 2025Open Access

Activation of nuclear receptors correlates with tuberculosis severity and is a target for host-directed therapy

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Authors

AMAna Raquel MaceirasMSMarta SilvaJCJoana Couto

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Overview

Pharmacologic LXR activation improves outcomes in tuberculosis, suggesting the SNR pathway as a severity biomarker.

Key Points

  • Core finding reveals that the SNR pathway correlates with tuberculosis severity in patients and mouse models.
  • Evidence indicates that LXR activation is linked to improved infection outcomes and prolonged survival in susceptible mice.
  • The approach used includes analyzing the SNR pathway expression in whole blood and examining LXR activation in lung infections.
  • This work advances the understanding of tuberculosis treatment by highlighting LXR as a target for host-directed therapy.

Cite This Study

Maceiras et al. (2025) studied this question.

synapsesocial.com/papers/689a0627e6551bb0af8ce03chttps://doi.org/10.1101/2025.07.23.666296
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