Synthesis of triazolo- and tetrazolo-fused 1,4-benzodiazepines via one-pot Ugi-azide and Cu-free click reactions

Xiaoming Ma; Zhiwei Gao; Jiawei Niu; Wen Shao; Shenghu Yan; Sai Zhang; Wei Zhang

doi:10.3762/bxiv.2025.48.v1

July 24, 2025Open Access

Synthesis of triazolo- and tetrazolo-fused 1,4-benzodiazepines via one-pot Ugi-azide and Cu-free click reactions

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Key Points

The synthesis method creates polycyclic scaffolds featuring triazole and tetrazole rings alongside benzodiazepines.
A one-pot approach combines Ugi-azide reactions with Cu-free cycloaddition to streamline the process.
Polycyclic structure 7 and a potential more complex scaffold 8 can be formed with this technique.
This method offers a novel route for synthesizing diverse bicyclic compounds in organic chemistry.

Implication

One-pot Ugi-azide method produces complex benzodiazepine scaffolds indicating potential for diverse compounds.

Abstract

A one-pot Ugi-azide reaction followed by intramolecular Cu-free azide-alkyne cycloaddition generates a polycyclic scaffold 7 bearing polycyclic triazole, tetrazole and benzodiazepine rings. This method could be extended for making a more complicated scaffold 8 containing piperazinone ring.

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Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/689a0627e6551bb0af8ce192 https://doi.org/10.3762/bxiv.2025.48.v1

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Synthesis of triazolo- and tetrazolo-fused 1,4-benzodiazepines via one-pot Ugi-azide and Cu-free click reactions

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis of triazolo- and tetrazolo-fused 1,4-benzodiazepines via one-pot Ugi-azide and Cu-free click reactions

Key Points

Implication

Abstract

Discussion

Cite This Study

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