July 25, 2025CureusOpen Access

Predictive Biomarkers in Cancer Immunotherapy: A Narrative Review Across Selected Solid Tumors

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Discussion

Narrative review explores predictive biomarkers in melanoma, NSCLC, and colorectal cancer, suggesting implications for treatment efficacy.

Main finding highlights critical predictive and prognostic biomarkers for cancer immunotherapy in various solid tumors.
Clinically validated biomarkers like PD-L1 and MSI-H show utility, but challenges exist due to tumor heterogeneity.
Emerging biomarkers such as TILs and REC may enhance predictions but require further validation to confirm efficacy.
This review underscores the importance of integrating validated and emerging biomarkers for improved real-world cancer treatment applications.

Puntambekar et al. (2025) studied this question.

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Narrative review explores predictive biomarkers in melanoma, NSCLC, and colorectal cancer, suggesting implications for treatment efficacy.