This review outlines folliculogenesis and the role of granulosa cells in fertility, highlighting key hormonal influences.
Follicle formation is a critical determinant of the size of the primordial follicle pool and is essential for fertility. This process occurs during definitive histogenesis. Follicles secrete essential hormones required for proper endocrine functioning and are also the chief suppliers of steroid sex hormones. Additionally, they also produce other local regulators. Throughout childhood and puberty, the human ovary presents differences in the follicle population. Ovarian granulosa cells play a significant role in every stage of follicular growth through proliferation, steroidogenesis and production of autocrine and paracrine factors. This review outlines the events of folliculogenesis at different stages and the factors influencing this complex pathway.
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Sumi Elizebeth Reny (2025) studied this question.
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