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July 25, 2025Open Access

Identification of RNA binding proteins that mediate a quality control mechanism of splicing

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Authors

MAMaram ArafatVGValer GoteaMUMubarak Ishaq Umar

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Overview

Genetic screening identified RNA binding proteins that enhance latent splice site usage, suggesting new regulatory pathways in splicing accuracy.

Key Points

  • Main finding reveals RNA binding proteins are crucial for suppressing latent splice site activation.
  • Genetic screen employed siRNA library to identify five RBPs impacting splicing mechanism.
  • Analysis confirmed widespread activation of latent splice sites in hundreds of mRNAs upon RBP knockdown.
  • Study uncovers ALYREF's significant role in maintaining splicing accuracy within the spliceosome.

Cite This Study

Arafat et al. (2025) studied this question.

synapsesocial.com/papers/689a0627e6551bb0af8ce227https://doi.org/10.1101/2025.07.20.665773
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