Integration of dilution-controlled AF4 with SAXS and SANS reveals structural details in lipid nanoparticles, suggesting enhanced nanoparticle design strategies.
Key Points
Joint SAXS and SANS techniques effectively analyze lipid nanoparticles down to ~5 nm in size.
Coupling dilution-controlled AF4 with scattering methods amplifies detection of structural heterogeneity.
Surfactant identity significantly influences the shape and polydispersity of lipid nanoparticles.
This new platform enhances the understanding of nanoparticle systems crucial for biomedical applications.