Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 26, 2025CellsOpen Access

Dual Roles of Hypoxia-Inducible Factor 1 in Acute Lung Injury: Tissue-Specific Mechanisms and Therapeutic Modulation

View Full Paper
Ask AI
Bookmark
Share

Authors

JJJunjing JiaYZYingyi ZhangQLQianying Lu

Discussion

Loading...

Member takes

Overview

Review examines hypoxia-inducible factor's impact on inflammation and repair in acute lung injury, suggesting potential therapeutic targets.

Key Points

  • HIF-1 plays a dual role in acute lung injury, influencing both inflammation and tissue repair processes.
  • Research highlights the importance of the alveolar-capillary barrier integrity in the progression of acute lung injury.
  • Therapeutic modulation targeting HIF-1 may promote recovery while managing inflammation in patients with acute lung injury.
  • Understanding hypoxia's effects can lead to innovative treatment strategies for acute lung injury management.

Cite This Study

Jia et al. (2025) studied this question.

synapsesocial.com/papers/689a0933e6551bb0af8ce524https://doi.org/10.3390/cells14141089
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hypoxia Exacerbates Inflammatory Acute Lung Injury via the Toll-Like Receptor 4 Signaling Pathway2018 · 94 citations
  2. 2Hypoxia: a critical pathophysiological driver in respiratory inflammatory diseases2026
  3. 3LDHA Regulates the Inflammatory Response in Acute Lung Injury Through Metabolic Reprogramming of Vascular Muscle Cells2026
  4. 4HIF-1α: a bridge connecting sepsis and acute respiratory distress syndrome2025
  5. 5Unraveling the role of HIF-1α in sepsis: from pathophysiology to potential therapeutics—a narrative review2024 · 47 citations