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July 26, 2025MicrobiologyOpenOpen Access

Prevalence of Antimicrobial Resistance in Klebsiella pneumoniae in the South African Populations: A Systematic Review and Meta‐Analysis of Surveillance Studies

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Authors

SYSinethemba H. YakobiUniversity of Fort HareUNUchechukwu U. NwodoUniversity of Fort Hare

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Overview

Systematic review reveals high antimicrobial resistance rates in Klebsiella pneumoniae isolates, highlighting urgent need for interventions and improved surveillance strategies.

Key Points

  • Pooled resistance prevalence for amoxicillin reached 69.3%, indicating serious treatment challenges.
  • Resistance rates for second-generation cephalosporins were reported as high as 70.9%, suggesting widespread effectiveness issues.
  • Nineteen studies examining 9402 isolates were analyzed using random-effects models to evaluate AMR.
  • Urgent multisectoral interventions are needed to address the alarming resistance rates to first-line antibiotics in South Africa.

Cite This Study

Yakobi et al. (2025) studied this question.

synapsesocial.com/papers/689a0933e6551bb0af8ce52dhttps://doi.org/10.1002/mbo3.70037
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