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July 26, 2025Cancer Biology and MedicineOpen Access

Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategies

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Authors

ZLZiyou LinTongji UniversityCCChang ChangChina Geological SurveySZShuyu ZhaoShanghai Dianji University

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Implication

This review uncovers how amino acids regulate tumor immunity and growth, highlighting therapeutic strategies like CAR-T cell therapy.

Key Points

  • The tumor immune microenvironment (TIME) is shaped by amino acids affecting immune evasion and tumor progression.
  • Key insights reveal how amino acid metabolism influences tumor cell growth and immune cell function within the TIME.
  • Emerging therapeutic strategies, including CAR-T cell therapy, target amino acid metabolism to potentially reprogram the TIME.
  • This comprehensive review highlights future research directions for clinical applications of amino acid-targeted interventions.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/689a0933e6551bb0af8ce561https://doi.org/10.20892/j.issn.2095-3941.2025.0115
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