July 26, 2025Open Access

Effective Aerosol Inoculation of Dose-Escalated Seasonal Influenza H3N2 Virus in Controlled Human Infection Model

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Dose-escalation study assesses aerosol delivery of influenza H3N2, showing effective infection rates in healthy adults.

Aerosol delivery methods for influenza H3N2 showed infection rates of 75% and 50% using FMAG and nebulizer, respectively.
Common symptoms from the challenge included sinus congestion, rhinorrhea, and cough, but no serious adverse events occurred.
Viral shedding was consistent across respiratory sites, and seroconversion occurred in 33% of infected participants.
Findings indicate that aerosol inoculation mimics natural infection more accurately than traditional intranasal methods.

Rouphael et al. (2025) studied this question.

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