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July 27, 2025Open Access

Cytisine for smoking cessation: A systematic review and meta-analysis suggesting potential benefits of extended treatment protocols

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Authors

YTYoshiyasu TonguWSWataru SakaiKKK Kinoshita

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Overview

Systematic review demonstrates cytisine's effectiveness in increasing quit rates in adult smokers, suggesting improvements to treatment guidelines.

Key Points

  • Cytisine treatment significantly increased quit rates with a risk ratio of 2.99, showing its efficacy as a smoking cessation aid.
  • Longer, fixed-dose regimens of cytisine resulted in higher quit rates compared to traditional 25-day tapering protocols.
  • The analysis included 3,847 adult smokers from seven randomized controlled trials across multiple countries.
  • Findings suggest a shift in clinical guidelines to include extended cytisine regimens as a standard smoking cessation treatment.

Cite This Study

Tongu et al. (2025) studied this question.

synapsesocial.com/papers/689a0939e6551bb0af8ce71dhttps://doi.org/10.1101/2025.07.23.25332030
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy and safety of cytisine versus nortriptyline for smoking cessation: A multicentre, randomized, double‐blinded and placebo‐controlled trial2024 · 3 citations
  2. 2Cytisine for smoking cessation: A 40-day treatment with an induction period2024 · 4 citations
  3. 3Safety and efficacy of CyTisine for smoking cessation in a hOSPital context (CITOSP): study protocol for a prospective observational study2024 · 5 citations
  4. 4Effectiveness of pharmacological smoking cessation treatments: a retrospective comparison of common methods2025
  5. 5Cytisine—New Challenges of a Well-Known Drug in the Treatment of Nicotine Addiction2026