A Comprehensive Review of Chronobiological Challenges of the Sleep-Wake Cycle in Space: Implications for Long-Duration Space Missions and Translational Applications in Terrestrial Medicine

Solaiman Hossain; Tanoy Saha; Md Ariful Islam; K M Ferdousul Haque; Md Mirazul Islam; Md Mahbubul Hoque; Sumiya Sharmin Mou

doi:10.3329/bpj.v28i2.83235

July 27, 2025Bangladesh Pharmaceutical JournalOpen Access

A Comprehensive Review of Chronobiological Challenges of the Sleep-Wake Cycle in Space: Implications for Long-Duration Space Missions and Translational Applications in Terrestrial Medicine

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Key Points

Maintaining a healthy sleep-wake cycle is crucial for astronaut performance on long-duration space missions.
Space environments disrupt circadian rhythms, leading to sleep disturbances and cognitive impairments that affect health.
Current countermeasures include light exposure manipulation, pharmacological interventions, and behavioral strategies.
Research on astronaut sleep issues may inform treatments for sleep disorders in the general population.],
simple_explanation
space can interfere with the body's natural sleep-wake cycle. This disrupts sleep and affects how astronauts think and perform. Finding solutions can help not only astronauts but also those on Earth with sleep problems.🌌
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Implication

This review highlights sleep-wake cycle disruptions in astronauts on space missions, indicating potential solutions and medical applications for Earth.

Abstract

Maintaining a healthy sleep-wake cycle is vital for the health and performance of astronauts on longduration space missions. The unique session type induced by space environments (high levels of microgravity and the absence of a day-night cycle) disrupts physiological circadian rhythms and adversely affects health status primarily through sleep disturbances and cognitive impairments that lead to reduction in performance. This review discusses the chronicles made by the astronauts in the space like the reflection of sleep-wake cycle disturbances with their mechanisms and biological and psychological effects of the astronauts due to these disturbances. It also discusses current countermeasures such as manipulation of exposure to light, pharmacological interventions, exercise regimens and behavioral strategies to mitigate these effects. The review emphasizes the importance of personalized and multimodal approaches for enhancing astronaut health during missions. Moreover, space research has potential applications to terrestrial medicine, especially in the management of sleep disorders and circadian rhythm misalignment in non-astronaut populations. Bangladesh Pharmaceutical Journal 28(2): 240-249, 2025 (July)

Discussion

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Cite This Study

Hossain et al. (2025) studied this question.

synapsesocial.com/papers/689a0939e6551bb0af8ce7db https://doi.org/10.3329/bpj.v28i2.83235

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A Comprehensive Review of Chronobiological Challenges of the Sleep-Wake Cycle in Space: Implications for Long-Duration Space Missions and Translational Applications in Terrestrial Medicine

Key Points

Implication

Abstract

Discussion

Cite This Study

A Comprehensive Review of Chronobiological Challenges of the Sleep-Wake Cycle in Space: Implications for Long-Duration Space Missions and Translational Applications in Terrestrial Medicine

Key Points

Implication

Abstract

Discussion

Cite This Study

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