July 28, 2025MedCommOpen Access

Toll‐Like Receptors in the Immunotherapy Era: Dual‐Edged Swords of Tumor Immunity and Clinical Translation

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Review highlights the dual-sided impact of toll-like receptors on tumor immunity and their therapeutic potential in various cancers.

Toll-like receptors are crucial in immune responses and play a dual role in tumor immunity.
These receptors can both activate antitumor immune responses and promote tumor progression in certain cases.
Recent advancements in TLR signaling pathways are enhancing their application in tumor therapy.
Understanding TLRs’ complex roles could lead to better-targeted therapies and improved cancer outcomes.

Maihemuti et al. (2025) studied this question.

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