July 28, 2025Brain SciencesOpen Access

The Crucial Interplay Between the Lungs, Brain, and Heart to Understand Epilepsy-Linked SUDEP: A Literature Review

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Discussion

Literature review highlights cardiac and pulmonary dysfunction in epilepsy, suggesting multidisciplinary interventions may reduce SUDEP risk.

Main finding indicates SUDEP is linked to seizures causing respiratory and cardiac failures.
Key evidence shows generalized tonic–clonic seizures lead to apnea, hypoventilation, and arrhythmias.
The approach involved examining literature across experimental models and neuroimaging studies.
Significance lies in highlighting modifiable risk factors and the need for integrated care in prevention strategies.

Mir et al. (2025) studied this question.

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Literature review highlights cardiac and pulmonary dysfunction in epilepsy, suggesting multidisciplinary interventions may reduce SUDEP risk.