July 28, 2025Open Access

Alcohol-related liver disease disrupts bile acid synthesis and is associated with compensatory gut microbiota changes

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Authors

MKM. KellerEuropean Molecular Biology Laboratory AZAndressa de ZawadzkiSteno Diabetes Centers MTMaja ThieleUniversity of Southern Denmark

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Implication

Cross-sectional analysis reveals altered bile acid synthesis and gut microbiota in individuals with alcohol-related liver disease, suggesting a key link in disease progression.

Key Points

Alcohol-related liver disease impacts bile acid metabolism and is linked to increased gut microbiota changes.
Advanced fibrosis leads to reduced bile acid transport but higher levels of primary and secondary bile acids in circulation.
Microbial pathways involved in bile acid metabolism shift with disease severity, indicating community-level microbial imbalances.
Identifying key gut microbes like Eggerthella lenta highlights the gut-liver axis's role in alcohol-related liver disease progression.

Cite This Study

Keller et al. (2025) studied this question.

synapsesocial.com/papers/689a093fe6551bb0af8ceb5b https://doi.org/10.1101/2025.07.23.25332046

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Implication

Cross-sectional analysis reveals altered bile acid synthesis and gut microbiota in individuals with alcohol-related liver disease, suggesting a key link in disease progression.

Alcohol-related liver disease disrupts bile acid synthesis and is associated with compensatory gut microbiota changes

Discussion

Member takes

Implication

Key Points

Cite This Study

Alcohol-related liver disease disrupts bile acid synthesis and is associated with compensatory gut microbiota changes

Discussion

Member takes

Implication

Key Points

Cite This Study

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