Case presentation details supratentorial ependymoma metastasis, highlighting diagnostic and therapeutic challenges.
Ependymomas are categorized based on anatomical location and specific genetic alterations, with extra‐axial metastasis being a rare event, occurring in less than 1% of cases and documented sparsely in the literature. This case study details a 27‐year‐old male patient diagnosed with supratentorial ependymoma characterized by Zinc Finger Translocation Associated ( ZFTA ) fusion and World Health Organization (WHO) Grade 2 morphology. Additionally, a systematic review of all reported cases of extra‐axial ependymoma metastases was conducted, systematically compiling clinical, morphological, and molecular data from relevant articles. Metastatic ependymoma represents a rare occurrence characterized by diagnostic and therapeutic challenges. A comprehensive review of the literature could provide valuable insights into the underlying biology and support the selection of optimal treatment strategies for such cases.
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Tran et al. (2025) studied this question.
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