July 30, 2025Digestive DiseasesOpen Access

Adult FPIES: A Review of Emerging Evidence and Clinical Considerations

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This review describes the gastrointestinal symptoms and triggers of adult-onset FPIES, implying the need for awareness among healthcare providers.

FPIES is a non-IgE-mediated reaction in adults, presenting with gastrointestinal symptoms after food intake.
Common symptoms include abdominal pain, diarrhea, and nausea, typically appearing one to four hours post-ingestion.
Food triggers for adult-onset FPIES often include seafood, with egg, wheat, and cow’s milk also identified.
Oral food challenge is highlighted as the gold standard for diagnosing FPIES in both adults and children.

Ahmed et al. (2025) studied this question.

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This review describes the gastrointestinal symptoms and triggers of adult-onset FPIES, implying the need for awareness among healthcare providers.