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July 30, 2025Reproductive Biology and EndocrinologyOpen Access

The establishment of lipid profiles reference ranges during pregnancy: a systematic review and meta-analysis

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Authors

LSLiyun SunBGBingrui GaoMWMingyue Wang

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Overview

Systematic review establishes trimester-specific reference ranges for lipid levels in pregnant women, highlighting potential dyslipidaemia risks.

Key Points

  • Establishing trimester-specific reference intervals for lipid levels is essential for maternal health during pregnancy.
  • Pooled means for total cholesterol ranged from 3.00-5.83 mmol/L in the first trimester to 4.39-8.98 mmol/L in the third trimester.
  • Factors influencing lipid levels may include assay methods, region of study, and the year of the research conduction.
  • Region-specific reference ranges enhance the accuracy of diagnosing dyslipidaemia in pregnant women.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/689a0945e6551bb0af8cee8fhttps://doi.org/10.1186/s12958-025-01450-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trimester‐specific reference intervals for maternal serum lipids and their associations with adverse outcomes in a cohort from China2025
  2. 2Trimester-specific lipid profile reference intervals in healthy pregnant women; A cross-sectional study at Debre Markos comprehensive specialized hospital, 2022/20232026
  3. 3Establishment of pregnancy-specific lipid reference intervals in pregnant women in a single-centre and assessment of the predictive value of early lipids for gestational diabetes mellitus: a prospective cohort study2024 · 4 citations
  4. 4Impacts of maternal lipid and homocysteine levels on the risks of pregnancy complications and adverse outcomes in both singleton and twin pregnancies: a population-based observational cohort study2026
  5. 5Associations of trimester–specific maternal lipid levels with abnormal foetal birth weights: a cohort study2026