The Impact of X‐ray Damage in Chemical Crystalline Materials and New Opportunities for Small Molecule Serial Crystallography

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This review discusses X-ray-induced effects in chemical crystalline materials, suggesting new approaches for small molecule crystallographers.

X-ray damage in chemical crystalline materials challenges traditional views on radiation damage significance.
Increased reports of X-ray-induced processes highlight the need for attention in small molecule crystallography.
New methodologies for quantifying and mitigating X-ray effects on single-crystal and microcrystalline powder samples are explored.
This review offers insights into recent investigations that could enhance the field of crystallography.

Lewis et al. (2025) studied this question.

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This review discusses X-ray-induced effects in chemical crystalline materials, suggesting new approaches for small molecule crystallographers.