July 30, 2025LifeOpen Access

Efficacy of Fertility-Sparing Treatments for Early-Stage Endometrial Cancer—Oncologic and Reproductive Outcomes: Protocol of a Systematic Review and Meta-Analysis

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Discussion

Systematic review and meta-analysis assess fertility-sparing treatments for endometrial cancer, indicating the need for updated clinical guidelines.

Fertility-sparing treatments for early-stage endometrial cancer may preserve reproductive potential.
Current guidelines recommend progestin-based therapies, but evidence quality is moderate to low.
Data on complete response and long-term fertility outcomes are critical for assessing treatment efficacy.
The review aims to identify evidence gaps to guide future research on fertility preservation strategies.

Keszthelyi et al. (2025) studied this question.

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Systematic review and meta-analysis assess fertility-sparing treatments for endometrial cancer, indicating the need for updated clinical guidelines.