Comprehensive review highlights endoscopic gastric remodeling's effectiveness in treating obesity, suggesting new therapeutic pathways for metabolic health.
Obesity has become a global epidemic, posing significant health challenges for individuals and straining healthcare systems worldwide. Endoscopic bariatric and metabolic therapies have emerged as an evolving field, characterized by their minimally invasive, reversible, and organ-preserving nature. This modality offers a promising alternative to traditional bariatric surgery. Various endoscopic therapies targeting the stomach and small bowel have been developed. Among these, endoscopic gastric remodeling interventions have demonstrated superior effectiveness and durability. These procedures utilize endoscopic tissue approximation devices to perform full-thickness suturing or plication of the gastric wall, thereby restricting the stomach volume and altering gastric motility to induce early satiety. This review aims to provide a comprehensive summary of the different endoscopic gastric remodeling interventions and discuss potential future developments in this rapidly evolving field, which holds the promise of offering an alternative therapeutic approach to the management of the global obesity epidemic.
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Ng et al. (2025) studied this question.
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