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July 30, 2025Open Access

Molecular Epidemiology of Infections Caused by Carbapenem-Resistant Pseudomonas aeruginosa and Enterobacterales and Susceptibility of Isolates to Ceftazidime-Avibactam

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Authors

JGJose-Rita GergesSBSara BaradaHHHadi Hussein

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Overview

Phenotypic and genotypic analysis reveals high carbapenem and ceftazidime-avibactam resistance in pathogens, indicating urgent treatment challenges.

Key Points

  • 100% of Klebsiella pneumoniae and 63% of Escherichia coli isolates were carbapenem-resistant.
  • 73% of Klebsiella pneumoniae, 79% of Escherichia coli, and 60% of Pseudomonas aeruginosa were resistant to ceftazidime-avibactam.
  • Whole-genome sequencing identified various sequence types, plasmids, and antimicrobial resistance genes among the isolates.
  • Ceftazidime-avibactam resistance involves multiple factors, including efflux pump overexpression and β-lactamase mutations.

Cite This Study

Gerges et al. (2025) studied this question.

synapsesocial.com/papers/689a0945e6551bb0af8cf064https://doi.org/10.20944/preprints202507.2149.v1
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