July 30, 2025

Temporal sequence of amyloid and tau PET positivity: APOE-ϵ4 and sex effects, and implications for Alzheimer's disease progression

View Full Paper

Ask AI

Bookmark

APOE-ε4 carriers and women showed earlier amyloid and tau PET positivity ages.
A shorter amyloid-tau interval predicted earlier symptom onset and faster cognitive decline.
Longitudinal observational study analyzed 792 amyloid PET and 212 tau PET positive participants.
Findings suggest that APOE-ε4 and sex are key factors in Alzheimer's disease progression timelines.

Discussion

No takes yet. Share an insight, caveat, or question.

Longitudinal study shows amyloid-tau interval influences symptom onset in Alzheimer's, indicating APOE-ε4 and sex modify risks.

Milà‐Alomà et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark