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July 31, 2025Journal of Neurology Neurosurgery & Psychiatry

From the past to the present: evolving theories in the pathophysiology of normal pressure hydrocephalus

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Authors

ABAdéla BubeníkováVPVáclav ProcházkaDVDominik Vacínek

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Overview

Review explores pathophysiology and classification of normal pressure hydrocephalus, suggesting avenues for future research.

Key Points

  • Normal pressure hydrocephalus (NPH) is characterized by gait disturbance, urinary incontinence, and cognitive impairment.
  • Dysfunction of the glymphatic system and neuroinflammatory processes are crucial in understanding NPH's pathophysiology.
  • The review highlights the importance of accurately classifying NPH to improve diagnosis and treatment strategies.
  • With an aging population, differentiating NPH from other neurodegenerative disorders is increasingly important for effective management.

Cite This Study

Bubeníková et al. (2025) studied this question.

synapsesocial.com/papers/689a094be6551bb0af8cf203https://doi.org/10.1136/jnnp-2025-336076
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Normal Pressure Hydrocephalus in the Elderly: A Narrative Review of Diagnostic Complexity, Biomarker Potential, and Surgical Outcomes2025
  2. 2Idiopathic Normal Pressure Hydrocephalus: A Comprehensive Review2026 · 1 citations
  3. 3Clinical Characteristics and Recent Advances in the Diagnostic Approach for Idiopathic Normal Pressure Hydrocephalus2026
  4. 4Normal pressure hydrocephalus: current concepts in diagnosis and management focused on clinical decision2025
  5. 5Incidental Diagnosis of Normal Pressure Hydrocephalus in Elderly Patients Presenting With Acute Neurological Illnesses: A Report of Two Cases2025