July 31, 2025

A general strategy for light-mediated nickel-catalyzed C(sp2)-heteroatom cross-couplings

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Main finding highlights a novel strategy for light-mediated nickel-catalyzed cross-couplings with low catalyst loadings.
The new catalytic system simplifies the use of diverse substrates, including challenging tertiary alcohols, without needing a photocatalyst.
This method allows oxidative addition on NiI with a specifically designed ligand, addressing previous limitations in nickel loading and complexity.
The approach supports late-stage functionalization in pharmaceutical chemistry, facilitating significant advancements in synthesis efficiency.

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Implication

A new catalytic system simplifies C(sp2)–heteroatom cross-couplings, enabling gram-scale synthesis with low nickel loadings and no need for dedicated photocatalysts.

Cite This Study

Bena et al. (2025) studied this question.

synapsesocial.com/papers/689a094be6551bb0af8cf2c9 https://doi.org/10.26434/chemrxiv-2025-1czpp

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Implication

A new catalytic system simplifies C(sp2)–heteroatom cross-couplings, enabling gram-scale synthesis with low nickel loadings and no need for dedicated photocatalysts.

A general strategy for light-mediated nickel-catalyzed C(sp2)-heteroatom cross-couplings

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Discussion

Implication

Cite This Study

A general strategy for light-mediated nickel-catalyzed C(sp2)-heteroatom cross-couplings

Key Points

Discussion

Implication

Cite This Study

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