July 31, 2025

Wastewater intelligence predicts the emergence of clinically-relevant and drug-resistant Candida auris at healthcare facilities

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Authors

CCChing-Lan ChangUniversity of Nevada, Las Vegas MMMichael A. MoshiUniversity of Nevada, Las Vegas QNQuang‐Huy NguyenAuburn University

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Implication

Monitoring wastewater at healthcare facilities identifies antifungal resistance trends in Candida auris, indicating improved public health surveillance.

Key Points

Wastewater-based epidemiology significantly improves the sensitivity of detecting drug-resistant Candida auris infections.
Upstream sewer monitoring at healthcare facilities revealed >90% genomic concordance with clinical isolates.
Novel resistance mutations in Candida auris were detected in wastewater samples months before appearing in clinics.
Transcriptomic profiling uncovered new adaptation mechanisms in drug-resistant Candida auris under stress conditions.

Cite This Study

Chang et al. (2025) studied this question.

synapsesocial.com/papers/689a094be6551bb0af8cf4ca https://doi.org/10.1101/2025.07.29.25332388

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Implication

Monitoring wastewater at healthcare facilities identifies antifungal resistance trends in Candida auris, indicating improved public health surveillance.

Wastewater intelligence predicts the emergence of clinically-relevant and drug-resistant Candida auris at healthcare facilities

Discussion

Member takes

Implication

Key Points

Cite This Study

Wastewater intelligence predicts the emergence of clinically-relevant and drug-resistant Candida auris at healthcare facilities

Discussion

Member takes

Implication

Key Points

Cite This Study

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