Role of monocarboxylate transporters in cancer immunology and their therapeutic potential

View Full Paper

Ask AI

Bookmark

Authors

Discussion

This review highlights MCTs' roles in cancer metabolism and their synergistic potential with immunotherapy, indicating new therapeutic strategies.

Monocarboxylate transporters (MCTs) regulate cancer cell metabolism and immune responses, influencing tumor progression.
Initial trials with MCT inhibitors like AZD3965 show promising results for enhancing cancer therapy efficacy.
Targeting MCTs can disrupt metabolic symbiosis in tumors, improving immune responses against cancer.
Combining MCT inhibitors with immune checkpoint blockade demonstrates enhanced antitumor immunity.

Faghihkhorasani et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark

This review highlights MCTs' roles in cancer metabolism and their synergistic potential with immunotherapy, indicating new therapeutic strategies.