July 31, 2025Cell RegenerationOpen Access

The comprehensive progress of tooth regeneration from the tooth development to tissue engineering and clinical application

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This review highlights tissue engineering, stem cell applications, and progresses in pulp-dentin regeneration technology for clinical use.

MAIN FINDING: Tooth regeneration technologies are evolving for treating tooth defects and loss.
KEY EVIDENCE: Pulp-dentin regeneration has shown preliminary efficacy in clinical trials, requiring further refinement.
APPROACH: The review analyzes biological foundations, stem cell applications, and challenges in tissue engineering.
SIGNIFICANCE: Advances in regeneration technology could revolutionize treatments for tooth loss and functional challenges.

Sui et al. (2025) studied this question.

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This review highlights tissue engineering, stem cell applications, and progresses in pulp-dentin regeneration technology for clinical use.