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July 31, 2025PharmaceuticsOpen Access

Preclinical Trials of Cancer Stem Cells Targeted by Metal-Based Coordination Complexes: A Systematic Review

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Authors

ABAna BezerraLBL BaptistaMCM. S. Couto

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Overview

Systematic review assesses cytotoxic effects of metal-based coordination complexes on cancer stem cells, implying their therapeutic potential.

Key Points

  • Metal-based coordination complexes, especially copper compounds, targeting cancer stem cells showed strong cytotoxicity.
  • Studies revealed significant induction of apoptosis in CSCs, suggesting effective therapeutic mechanisms.
  • Review included 27 in vitro studies focused on the effects of metal compounds on cancer cell lines with CSCs.
  • Further in vivo studies are necessary to evaluate the translational potential of these metal complexes in cancer therapy.

Cite This Study

Bezerra et al. (2025) studied this question.

synapsesocial.com/papers/689a0c5fe6551bb0af8cf6cdhttps://doi.org/10.3390/pharmaceutics17070931
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