Cu/Ir-catalysis generates diverse products with up to three stereogenic centers from electron deficient alkenes, suggesting new routes for complex molecule synthesis.
Polyfunctional molecules bearing multiple stereogenic centers are synthetically valuable and important for com-plex structure preparation. Herein, a Cu/Ir-catalyzed borylallylation of electron deficient alkenes is presented. The reaction operates by the cooperative function of a chiral Cu-complex and a chiral Ir-complex to generate products with high levels of stereocontrol. The method also allows for the stereodivergent synthesis of acyclic products with control of three stereogenic centers. Im-portantly, the products contain C-B, ester, and alkene functionalities, which allows for a diverse range of prod-ucts to be generated.
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Das et al. (2025) studied this question.
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