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July 31, 2025

Mapping the Inter- and Intra-genic Codon Usage Landscape in Homo sapiens

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Authors

MAMaahil ArshadMUMatthew UchmanowiczVRV.B. Rana

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Overview

Research reveals codon usage bias influences protein folding and genomic integrity in Homo sapiens, indicating potential regulatory roles.

Key Points

  • Codon usage bias significantly affects translational efficiency and protein folding in Homo sapiens.
  • The study found a correlation between high tRNA gene copy numbers and frequently used codons, with p < 0.05.
  • Genes with extreme codon bias show fewer synonymous mutations than expected, with r = 0.28, p < 2.2.
  • These findings provide a new perspective on synonymous variation and its functional implications in genomics.

Cite This Study

Arshad et al. (2025) studied this question.

synapsesocial.com/papers/689a0c5fe6551bb0af8cf7d4https://doi.org/10.1101/2025.07.27.667039
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