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Cross-sectional study showed corneal hypersensitivity may precede structural nerve degeneration in Parkinson's disease patients.
Abstract This cross-sectional study assessed corneal nerve parameters in 53 participants—17 high-risk for Parkinson’s disease (PD), 18 PD, and 18 healthy controls. Corneal nerve density and length were highest in controls, intermediate in high-risk, and lowest in PD (p = 0.004, p = 0.020). Corneal sensitivity was paradoxically highest in the high-risk group (p = 0.02). These findings suggest corneal hypersensitivity may precede structural nerve degeneration in prodromal PD.
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Yaisawang et al. (2025) studied this question.