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July 31, 2025

Gentamicin alleviates intestinal graft-versus-host disease by modulating butyrate-associated gut microbiota

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Authors

LSLinlin ShaoYZYe ZhangYHYuefen Hu

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Overview

Mouse model demonstrated gentamicin reduces intestinal GVHD severity while butyrate worsens its effects, indicating complex interactions.

Key Points

  • Gentamicin significantly lessens mortality and GVHD scores in allo-HSCT mice.
  • Alterations in gut microbiota composition are noted with gentamicin treatment, lowering Clostridium levels.
  • Sodium butyrate caused increased mortality and exacerbated intestinal GVHD, linked to goblet cell apoptosis.
  • Timing of butyrate supplementation post-gentamicin illustrates a dual effect on GVHD outcomes.

Cite This Study

Shao et al. (2025) studied this question.

synapsesocial.com/papers/689a0c5fe6551bb0af8cf7e7https://doi.org/10.21203/rs.3.rs-7181845/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gut microbiota recovery via butyrate supplementation prevents acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation2025
  2. 2Control of gvhd by probiotics with a single strain of muribaculaceae bacterium through secretory proteins2025 · 1 citations
  3. 3Assessment of Sodium Butyrate’s Pharmacological Effects on Gentamicin-induced Nephrotic Disorders in a Rat Model2024 · 1 citations
  4. 4Enteral supplementation with a TGF-β-enriched polymeric diet mitigates gastrointestinal acute gvhd2025
  5. 5Effect of GVHD on the gut and intestinal microflora2024 · 6 citations