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August 1, 2025

CD33 and Clusterin Interact Biophysically and Genetically to Modulate Alzheimer Risk

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Authors

RDRoger B. DoddMEMasahiro EnomotoYZYe Zhou

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Overview

Functional and genetic analysis reveals how CD33 and clusterin interactions impact Alzheimer's risk.

Key Points

  • CD33 genetic variants modify Alzheimer's disease risk, impacting microglial functions.
  • The full-length CD33 M isoform interacts with clusterin and amyloid-beta, decreasing phagocytosis.
  • Human brain expression data support that CLU and CD33 genotype interactions affect Alzheimer's symptoms.
  • Unexpected findings include a soluble form of CD33 M and variants altering its extracellular function.

Cite This Study

Dodd et al. (2025) studied this question.

synapsesocial.com/papers/689a0c65e6551bb0af8cf8dehttps://doi.org/10.1101/2025.07.29.667318
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk2026
  2. 2CD33-CD45 Interaction Reveals a Mechanistic Link to Alzheimer's Disease Susceptibility2025 · 4 citations
  3. 3CD33 Isoform Splicing Dysregulation: A Molecular Determinant of Microglial Dysfunction in Alzheimer's Disease Pathology.2026
  4. 4Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice2024 · 31 citations
  5. 5CD33 and SHP-1/PTPN6 Interaction in Alzheimer’s Disease2024 · 2 citations