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July 31, 2025

CD33-CD45 Interaction Reveals a Mechanistic Link to Alzheimer's Disease Susceptibility

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Authors

NVNicole VoCRCory D RillahanZCZena K. Chatila

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Overview

Research demonstrates increased CD33-CD45 interaction in Alzheimer's patients, suggesting immune system roles in disease susceptibility.

Key Points

  • MAIN FINDING: CD33-CD45 interaction contributes to Alzheimer's disease susceptibility through immune dysfunction.
  • KEY EVIDENCE: The rs3865444 CC risk variant leads to seven-fold increased expression of the full-length CD33 isoform.
  • APPROACH: The study examined binding interactions and effects on amyloid beta clearance in microglial-neuronal co-cultures.
  • SIGNIFICANCE: Understanding CD33 and CD45 interactions opens potential pathways for therapeutic interventions in Alzheimer's disease.

Cite This Study

Vo et al. (2025) studied this question.

synapsesocial.com/papers/689a0c65e6551bb0af8cf86ahttps://doi.org/10.1101/2025.07.28.667311
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CD33 and Clusterin Interact Biophysically and Genetically to Modulate Alzheimer Risk2025 · 3 citations
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  3. 3CD33 and SHP-1/PTPN6 Interaction in Alzheimer’s Disease2024 · 2 citations
  4. 4CD33 Isoform Splicing Dysregulation: A Molecular Determinant of Microglial Dysfunction in Alzheimer's Disease Pathology.2026
  5. 5CD33 and SHP-1/PTPN6 Interaction in Alzheimer’s Disease2024 · 5 citations